Drug interactions
Argatroban + Dong quai
Severity: Moderate
Argatroban and Dong quai: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dong quai contains coumarin derivatives and has been associated with increased INR and bleeding in patients taking warfarin. It may add to the bleeding risk with argatroban.
What this interaction means in plain words
Argatroban and Dong quai can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Coumarin constituents may have anticoagulant and antiplatelet effects adding to thrombin inhibition.
What to do
Avoid dong quai during argatroban therapy. Monitor aPTT and for bleeding if exposure has occurred.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Dong quai?
MediHelp rates the interaction as moderate. Argatroban and Dong quai can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dong quai contains coumarin derivatives and has been associated with increased INR and bleeding in patients taking warfarin. It may add to the bleeding risk with argatroban.
How serious is the interaction between Argatroban and Dong quai?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dong quai during argatroban therapy. Monitor aPTT and for bleeding if exposure has occurred.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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