Drug interactions
Argatroban + Erythromycin base
Severity: Minor
Argatroban and Erythromycin base: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4, which has a minor role in argatroban metabolism. In a pharmacokinetic study, erythromycin did not significantly change argatroban exposure, so a clinically important effect is unlikely.
What this interaction means in plain words
Argatroban and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak potential inhibition of CYP3A4/5-mediated argatroban metabolism, which is a minor clearance pathway.
What to do
No dose adjustment is usually needed. Continue to titrate argatroban to aPTT.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Erythromycin base?
MediHelp rates the interaction as minor. Argatroban and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4, which has a minor role in argatroban metabolism. In a pharmacokinetic study, erythromycin did not significantly change argatroban exposure, so a clinically important effect is unlikely.
How serious is the interaction between Argatroban and Erythromycin base?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Continue to titrate argatroban to aPTT.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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