Drug interactions
Argatroban + Ethinyl estradiol-levonorgestrel
Severity: Moderate
Argatroban and Ethinyl estradiol-levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Argatroban is a direct thrombin inhibitor used to treat thrombosis, whereas estrogen-containing contraceptives are prothrombotic. There is no recognized direct interaction, and any opposing effect is clinical rather than pharmacologic.
What this interaction means in plain words
Argatroban and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
No established mechanism; combined hormonal contraceptives increase clotting factors, which is a disease-related prothrombotic influence.
What to do
Avoid starting estrogen-containing contraceptives in patients being treated for acute thrombosis or HIT; consider progestin-only or non-hormonal methods.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Argatroban and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Argatroban is a direct thrombin inhibitor used to treat thrombosis, whereas estrogen-containing contraceptives are prothrombotic. There is no recognized direct interaction, and any opposing effect is clinical rather than pharmacologic.
How serious is the interaction between Argatroban and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting estrogen-containing contraceptives in patients being treated for acute thrombosis or HIT; consider progestin-only or non-hormonal methods.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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