Drug interactions
Argatroban + Factor x human
Severity: Moderate
Argatroban and Factor x human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Human coagulation factor X is given to restore clotting activity in hereditary factor X deficiency, whereas argatroban is a direct thrombin inhibitor that suppresses fibrin formation. Argatroban may blunt the hemostatic effect of the factor X concentrate. Legacy claim of Xa inhibitor antagonism does not apply to argatroban, which acts on thrombin.
What this interaction means in plain words
Argatroban and Factor x human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition: factor X replacement promotes thrombin generation while argatroban directly inhibits thrombin.
What to do
Avoid giving argatroban with factor X concentrate unless thrombosis risk clearly requires it. If both are needed, monitor clinical bleeding and coagulation tests (aPTT, factor X activity).
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Factor x human?
MediHelp rates the interaction as moderate. Argatroban and Factor x human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Human coagulation factor X is given to restore clotting activity in hereditary factor X deficiency, whereas argatroban is a direct thrombin inhibitor that suppresses fibrin formation. Argatroban may blunt the hemostatic effect of the factor X concentrate. Legacy claim of Xa inhibitor antagonism does not apply to argatroban, which acts on thrombin.
How serious is the interaction between Argatroban and Factor x human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving argatroban with factor X concentrate unless thrombosis risk clearly requires it. If both are needed, monitor clinical bleeding and coagulation tests (aPTT, factor X activity).
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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