Drug interactions
Argatroban + Fenbufen
Severity: Moderate
Argatroban and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen is an NSAID that inhibits platelet function and can cause gastric injury. With argatroban, the risk of bleeding is increased.
What this interaction means in plain words
Argatroban and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: NSAID platelet inhibition plus direct thrombin inhibition.
What to do
Avoid NSAIDs where possible and use paracetamol instead. If used together, monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Fenbufen?
MediHelp rates the interaction as moderate. Argatroban and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen is an NSAID that inhibits platelet function and can cause gastric injury. With argatroban, the risk of bleeding is increased.
How serious is the interaction between Argatroban and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible and use paracetamol instead. If used together, monitor for bleeding and hemoglobin.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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