Drug interactions
Argatroban + Fenoprofen
Severity: Major
Argatroban and Fenoprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen impairs platelet function and can injure the gastric mucosa, while argatroban is a direct thrombin inhibitor. Combined use raises the risk of bleeding, including gastrointestinal haemorrhage.
What this interaction means in plain words
Argatroban and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from NSAID platelet inhibition and direct thrombin inhibition.
What to do
Avoid NSAIDs during argatroban therapy where possible, and monitor aPTT and for signs of bleeding if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Fenoprofen?
MediHelp rates the interaction as major. Argatroban and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenoprofen impairs platelet function and can injure the gastric mucosa, while argatroban is a direct thrombin inhibitor. Combined use raises the risk of bleeding, including gastrointestinal haemorrhage.
How serious is the interaction between Argatroban and Fenoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs during argatroban therapy where possible, and monitor aPTT and for signs of bleeding if unavoidable.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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