Drug interactions
Argatroban + Feverfew
Severity: Minor
Argatroban and Feverfew: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew inhibits platelet aggregation in laboratory studies and is traditionally associated with bleeding tendency. It may add modestly to the bleeding risk of argatroban.
What this interaction means in plain words
Argatroban and Feverfew have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible platelet inhibition by parthenolide adding to thrombin inhibition.
What to do
Avoid feverfew supplements during argatroban therapy. Monitor for bleeding and aPTT.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Feverfew?
MediHelp rates the interaction as minor. Argatroban and Feverfew have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Feverfew inhibits platelet aggregation in laboratory studies and is traditionally associated with bleeding tendency. It may add modestly to the bleeding risk of argatroban.
How serious is the interaction between Argatroban and Feverfew?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid feverfew supplements during argatroban therapy. Monitor for bleeding and aPTT.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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