Drug interactions
Argatroban + Fluorouracil
Severity: Moderate
Argatroban and Fluorouracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil can cause thrombocytopenia and mucosal injury, which increase bleeding risk in anticoagulated patients. Argatroban is a direct thrombin inhibitor, so bleeding may be more likely or more severe.
What this interaction means in plain words
Argatroban and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Fluorouracil belongs to Oncology.
Why it happens
Additive pharmacodynamic bleeding risk from chemotherapy-induced thrombocytopenia plus anticoagulation.
What to do
Monitor platelet counts and aPTT or other coagulation parameters, and watch for bleeding. Adjust the argatroban dose, and consider holding it if platelets fall markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluorouracil
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Fluorouracil?
MediHelp rates the interaction as moderate. Argatroban and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluorouracil can cause thrombocytopenia and mucosal injury, which increase bleeding risk in anticoagulated patients. Argatroban is a direct thrombin inhibitor, so bleeding may be more likely or more severe.
How serious is the interaction between Argatroban and Fluorouracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and aPTT or other coagulation parameters, and watch for bleeding. Adjust the argatroban dose, and consider holding it if platelets fall markedly.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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