Drug interactions
Argatroban + Ginko biloba
Severity: Moderate
Argatroban and Ginko biloba: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginkgo biloba may impair platelet function and add to the bleeding risk of the direct thrombin inhibitor argatroban. Evidence is mostly case-based and theoretical.
What this interaction means in plain words
Argatroban and Ginko biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Ginko biloba belongs to Gastrointestinal Tract.
Why it happens
Ginkgo's platelet-activating factor antagonism adds antiplatelet effects to argatroban's anticoagulation.
What to do
Advise stopping ginkgo before starting argatroban. If it is continued, monitor aPTT and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ginko biloba
- Ginko biloba + Ketorolac Major
- Abciximab + Ginko biloba Moderate
- Aceclofenac + Ginko biloba Moderate
- Acemetacin + Ginko biloba Moderate
- Alteplase + Ginko biloba Moderate
- Anagrelide + Ginko biloba Moderate
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Ginko biloba?
MediHelp rates the interaction as moderate. Argatroban and Ginko biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginkgo biloba may impair platelet function and add to the bleeding risk of the direct thrombin inhibitor argatroban. Evidence is mostly case-based and theoretical.
How serious is the interaction between Argatroban and Ginko biloba?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise stopping ginkgo before starting argatroban. If it is continued, monitor aPTT and watch for bleeding.
What other medicines interact with Ginko biloba?
MediHelp also lists interactions of Ginko biloba with, for example, Ketorolac, Abciximab, Aceclofenac. The full list is on the Ginko biloba page.
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