Drug interactions
Argatroban + Hydrocortisone
Severity: Moderate
Argatroban and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter coagulation and also impair mucosal and vascular integrity, so bleeding risk may rise during anticoagulation with argatroban. Any pharmacokinetic interaction is not established.
What this interaction means in plain words
Argatroban and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects on bleeding risk (for example GI mucosal injury); no established kinetic mechanism.
What to do
Monitor aPTT as per argatroban protocol and watch for signs of bleeding, especially GI bleeding; consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Hydrocortisone?
MediHelp rates the interaction as moderate. Argatroban and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter coagulation and also impair mucosal and vascular integrity, so bleeding risk may rise during anticoagulation with argatroban. Any pharmacokinetic interaction is not established.
How serious is the interaction between Argatroban and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT as per argatroban protocol and watch for signs of bleeding, especially GI bleeding; consider gastroprotection in high-risk patients.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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