Drug interactions
Argatroban + Ketorolac intranasal
Severity: Major
Argatroban and Ketorolac intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac strongly inhibits platelet function and is itself labeled as contraindicated with anticoagulants because of bleeding risk. Intranasal ketorolac is systemically absorbed, so combining it with argatroban substantially raises bleeding risk.
What this interaction means in plain words
Argatroban and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment: COX inhibition with platelet dysfunction plus direct thrombin inhibition.
What to do
Avoid the combination and use a non-NSAID analgesic. If unavoidable, monitor closely for bleeding, especially gastrointestinal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Ketorolac intranasal?
MediHelp rates the interaction as major. Argatroban and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac strongly inhibits platelet function and is itself labeled as contraindicated with anticoagulants because of bleeding risk. Intranasal ketorolac is systemically absorbed, so combining it with argatroban substantially raises bleeding risk.
How serious is the interaction between Argatroban and Ketorolac intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-NSAID analgesic. If unavoidable, monitor closely for bleeding, especially gastrointestinal.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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