Drug interactions
Argatroban + Levonorgestrel intrauterine
Severity: Minor
Argatroban and Levonorgestrel intrauterine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Argatroban is used for thrombosis, notably in heparin-induced thrombocytopenia. The intrauterine levonorgestrel system has low systemic hormone exposure and a minimal effect on clotting, so a clinically meaningful antagonism is not expected. The legacy concern about thromboembolism is mainly relevant to systemic estrogen-containing products.
What this interaction means in plain words
Argatroban and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; systemic progestin exposure from the intrauterine system is low and has little effect on thrombin inhibition.
What to do
No change in argatroban dosing is needed. Continue routine aPTT monitoring of argatroban and reassess the contraceptive choice only if there is an independent thrombotic concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Levonorgestrel intrauterine?
MediHelp rates the interaction as minor. Argatroban and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Argatroban is used for thrombosis, notably in heparin-induced thrombocytopenia. The intrauterine levonorgestrel system has low systemic hormone exposure and a minimal effect on clotting, so a clinically meaningful antagonism is not expected. The legacy concern about thromboembolism is mainly relevant to systemic estrogen-containing products.
How serious is the interaction between Argatroban and Levonorgestrel intrauterine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change in argatroban dosing is needed. Continue routine aPTT monitoring of argatroban and reassess the contraceptive choice only if there is an independent thrombotic concern.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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