Drug interactions
Argatroban + Meclofenamate
Severity: Moderate
Argatroban and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate is an NSAID that impairs platelet function and can injure the gastrointestinal mucosa. With argatroban, bleeding risk is increased.
What this interaction means in plain words
Argatroban and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: NSAID platelet inhibition plus direct thrombin inhibition.
What to do
Prefer paracetamol or other non-NSAID analgesia. If combined, monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Meclofenamate?
MediHelp rates the interaction as moderate. Argatroban and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate is an NSAID that impairs platelet function and can injure the gastrointestinal mucosa. With argatroban, bleeding risk is increased.
How serious is the interaction between Argatroban and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or other non-NSAID analgesia. If combined, monitor for bleeding and hemoglobin.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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