Drug interactions
Argatroban + Mestranol
Severity: Major
Argatroban and Mestranol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol, an estrogen used in oral contraceptives, increases thrombotic risk and may counteract argatroban in patients with thrombosis.
What this interaction means in plain words
Argatroban and Mestranol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Estrogenic prothrombotic effects on clotting factors oppose thrombin inhibition.
What to do
Avoid estrogen-containing contraceptives during treatment of thrombosis; switch to a non-estrogen method.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Mestranol?
MediHelp rates the interaction as major. Argatroban and Mestranol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mestranol, an estrogen used in oral contraceptives, increases thrombotic risk and may counteract argatroban in patients with thrombosis.
How serious is the interaction between Argatroban and Mestranol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen-containing contraceptives during treatment of thrombosis; switch to a non-estrogen method.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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