Drug interactions
Argatroban + Phenobarbital
Severity: Minor
Argatroban and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a potent inducer of hepatic enzymes and could lower argatroban concentrations. Argatroban metabolism by CYP3A4/5 is a minor part of clearance, so any reduction is likely small and not well documented clinically.
What this interaction means in plain words
Argatroban and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical induction of hepatic metabolism of argatroban by phenobarbital.
What to do
No routine dose change. Adjust argatroban to aPTT targets and reassess when phenobarbital is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Phenobarbital?
MediHelp rates the interaction as minor. Argatroban and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital is a potent inducer of hepatic enzymes and could lower argatroban concentrations. Argatroban metabolism by CYP3A4/5 is a minor part of clearance, so any reduction is likely small and not well documented clinically.
How serious is the interaction between Argatroban and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change. Adjust argatroban to aPTT targets and reassess when phenobarbital is started or stopped.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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