Drug interactions
Argatroban + Sulfadiazine
Severity: Minor
Argatroban and Sulfadiazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamides are not established to alter argatroban kinetics to a meaningful degree. Argatroban is highly protein bound but displacement effects are not documented to be clinically significant.
What this interaction means in plain words
Argatroban and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical protein binding displacement or metabolic inhibition; no established clinically important mechanism.
What to do
No empirical dose change. Follow aPTT during argatroban therapy and watch for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Sulfadiazine?
MediHelp rates the interaction as minor. Argatroban and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamides are not established to alter argatroban kinetics to a meaningful degree. Argatroban is highly protein bound but displacement effects are not documented to be clinically significant.
How serious is the interaction between Argatroban and Sulfadiazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change. Follow aPTT during argatroban therapy and watch for bleeding.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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