Drug interactions
Argatroban + Thyroid desiccated
Severity: Minor
Argatroban and Thyroid desiccated: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones enhance catabolism of vitamin K-dependent clotting factors and so potentiate vitamin K antagonists. A clinically significant interaction with argatroban, a direct thrombin inhibitor, is not documented.
What this interaction means in plain words
Argatroban and Thyroid desiccated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Not established for argatroban; thyroid hormone accelerates clotting factor catabolism, relevant mainly to vitamin K antagonists.
What to do
No dose adjustment. Monitor aPTT as usual during argatroban therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Thyroid desiccated?
MediHelp rates the interaction as minor. Argatroban and Thyroid desiccated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thyroid hormones enhance catabolism of vitamin K-dependent clotting factors and so potentiate vitamin K antagonists. A clinically significant interaction with argatroban, a direct thrombin inhibitor, is not documented.
How serious is the interaction between Argatroban and Thyroid desiccated?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment. Monitor aPTT as usual during argatroban therapy.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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