Drug interactions
Aripiprazole + Artemether / lumefantrine
Severity: Moderate
Aripiprazole and Artemether / lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QT interval. Aripiprazole has a small QT liability, so combined use may increase the risk of arrhythmia, particularly with electrolyte disturbance or heart disease.
What this interaction means in plain words
Aripiprazole and Artemether / lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain an ECG before treatment if risk factors are present, correct electrolyte abnormalities, and monitor for palpitations or syncope. Consider an alternative antimalarial in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Artemether / lumefantrine?
MediHelp rates the interaction as moderate. Aripiprazole and Artemether / lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether/lumefantrine can prolong the QT interval. Aripiprazole has a small QT liability, so combined use may increase the risk of arrhythmia, particularly with electrolyte disturbance or heart disease.
How serious is the interaction between Aripiprazole and Artemether / lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before treatment if risk factors are present, correct electrolyte abnormalities, and monitor for palpitations or syncope. Consider an alternative antimalarial in high-risk patients.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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