Drug interactions
Aripiprazole + Belladonna alkaloids
Severity: Minor
Aripiprazole and Belladonna alkaloids: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids are anticholinergic and may add to the anticholinergic burden of aripiprazole, which has only weak antimuscarinic activity. Constipation, urinary retention, dry mouth, confusion and tachycardia are possible, particularly in older patients.
What this interaction means in plain words
Aripiprazole and Belladonna alkaloids have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive anticholinergic effects.
What to do
Monitor for anticholinergic effects such as constipation, urinary retention and confusion, especially in older adults, and reduce the belladonna dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Belladonna alkaloids?
MediHelp rates the interaction as minor. Aripiprazole and Belladonna alkaloids have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Belladonna alkaloids are anticholinergic and may add to the anticholinergic burden of aripiprazole, which has only weak antimuscarinic activity. Constipation, urinary retention, dry mouth, confusion and tachycardia are possible, particularly in older patients.
How serious is the interaction between Aripiprazole and Belladonna alkaloids?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as constipation, urinary retention and confusion, especially in older adults, and reduce the belladonna dose if they occur.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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