Drug interactions
Aripiprazole + Belladonna and opium
Severity: Moderate
Aripiprazole and Belladonna and opium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component adds opioid-related sedation and respiratory depression to the effects of aripiprazole, while belladonna adds anticholinergic effects. Together these can cause drowsiness, constipation, urinary retention and hypotension.
What this interaction means in plain words
Aripiprazole and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid and antipsychotic effects, plus additive anticholinergic effects.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function; counsel patients about driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Belladonna and opium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Belladonna and opium?
MediHelp rates the interaction as moderate. Aripiprazole and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component adds opioid-related sedation and respiratory depression to the effects of aripiprazole, while belladonna adds anticholinergic effects. Together these can cause drowsiness, constipation, urinary retention and hypotension.
How serious is the interaction between Aripiprazole and Belladonna and opium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function; counsel patients about driving and other hazardous activities.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
