Drug interactions
Aripiprazole + Benperidol
Severity: Moderate
Aripiprazole and Benperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on dopamine D2 receptors, and benperidol is a potent butyrophenone antipsychotic. Combined use increases the likelihood of extrapyramidal symptoms, sedation, QT effects and neuroleptic malignant syndrome without clear therapeutic benefit.
What this interaction means in plain words
Aripiprazole and Benperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 receptor antagonism or partial agonism, with additive CNS depression.
What to do
Avoid antipsychotic polypharmacy where possible; if combined, use the lowest effective doses and monitor for extrapyramidal symptoms, rigidity, fever and ECG changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Benperidol?
MediHelp rates the interaction as moderate. Aripiprazole and Benperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on dopamine D2 receptors, and benperidol is a potent butyrophenone antipsychotic. Combined use increases the likelihood of extrapyramidal symptoms, sedation, QT effects and neuroleptic malignant syndrome without clear therapeutic benefit.
How serious is the interaction between Aripiprazole and Benperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible; if combined, use the lowest effective doses and monitor for extrapyramidal symptoms, rigidity, fever and ECG changes.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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