Drug interactions
Aripiprazole + Brexanolone
Severity: Moderate
Aripiprazole and Brexanolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness in some patients, and combining it with other CNS depressants such as aripiprazole may increase this risk. Patients need monitoring throughout the infusion.
What this interaction means in plain words
Aripiprazole and Brexanolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the GABA-A positive modulation of brexanolone and the sedating effects of aripiprazole.
What to do
Monitor sedation and oxygen saturation continuously during the infusion. Interrupt or reduce the infusion if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Brexanolone?
MediHelp rates the interaction as moderate. Aripiprazole and Brexanolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes excessive sedation and sudden loss of consciousness in some patients, and combining it with other CNS depressants such as aripiprazole may increase this risk. Patients need monitoring throughout the infusion.
How serious is the interaction between Aripiprazole and Brexanolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation continuously during the infusion. Interrupt or reduce the infusion if excessive sedation occurs.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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