Drug interactions
Aripiprazole + Buprenorphine long-acting
Severity: Moderate
Aripiprazole and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting injectable buprenorphine provides sustained exposure with a small QT effect and CNS depression. With aripiprazole, these effects may be additive, though clinically modest.
What this interaction means in plain words
Aripiprazole and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and CNS depression.
What to do
Obtain a baseline ECG if cardiac risk factors are present, correct electrolytes, and monitor for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Buprenorphine long-acting, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Aripiprazole and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting injectable buprenorphine provides sustained exposure with a small QT effect and CNS depression. With aripiprazole, these effects may be additive, though clinically modest.
How serious is the interaction between Aripiprazole and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG if cardiac risk factors are present, correct electrolytes, and monitor for sedation.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
