Drug interactions
Aripiprazole + Buprenorphine transdermal
Severity: Moderate
Aripiprazole and Buprenorphine transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal buprenorphine has a labeled QT warning at higher doses and causes CNS depression. Combined with aripiprazole, arrhythmic risk and sedation may increase modestly.
What this interaction means in plain words
Aripiprazole and Buprenorphine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and CNS depression.
What to do
Monitor ECG in patients with cardiac risk factors or on high buprenorphine doses, and monitor for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Buprenorphine transdermal?
MediHelp rates the interaction as moderate. Aripiprazole and Buprenorphine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal buprenorphine has a labeled QT warning at higher doses and causes CNS depression. Combined with aripiprazole, arrhythmic risk and sedation may increase modestly.
How serious is the interaction between Aripiprazole and Buprenorphine transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors or on high buprenorphine doses, and monitor for sedation.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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