Drug interactions
Aripiprazole + Buprenorphine
Severity: Minor
Aripiprazole and Buprenorphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has a low potential to prolong QT, so a clinically important additive effect with buprenorphine is unlikely. Additive sedation is possible but usually modest.
What this interaction means in plain words
Aripiprazole and Buprenorphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Buprenorphine belongs to Musculoskeletal.
Why it happens
Possible small additive QT effect and CNS depression; aripiprazole is a weak QT prolonger.
What to do
No specific action is needed beyond monitoring for sedation. Check an ECG only if other QT risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Buprenorphine?
MediHelp rates the interaction as minor. Aripiprazole and Buprenorphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole has a low potential to prolong QT, so a clinically important additive effect with buprenorphine is unlikely. Additive sedation is possible but usually modest.
How serious is the interaction between Aripiprazole and Buprenorphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring for sedation. Check an ECG only if other QT risk factors are present.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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