Drug interactions
Aripiprazole + Butabarbital
Severity: Moderate
Aripiprazole and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital induces CYP3A4 and can lower aripiprazole concentrations, risking loss of antipsychotic efficacy. Both drugs also cause sedation, so central nervous system depression is additive.
What this interaction means in plain words
Aripiprazole and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by the barbiturate increases aripiprazole clearance, along with additive CNS depression.
What to do
Aripiprazole labeling advises about doubling the dose with strong CYP3A4 inducers; monitor clinical response and sedation, and reduce the dose again if the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Butabarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Butabarbital?
MediHelp rates the interaction as moderate. Aripiprazole and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital induces CYP3A4 and can lower aripiprazole concentrations, risking loss of antipsychotic efficacy. Both drugs also cause sedation, so central nervous system depression is additive.
How serious is the interaction between Aripiprazole and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Aripiprazole labeling advises about doubling the dose with strong CYP3A4 inducers; monitor clinical response and sedation, and reduce the dose again if the inducer is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
