Drug interactions
Aripiprazole + Butalbital
Severity: Moderate
Aripiprazole and Butalbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and lower aripiprazole exposure, although occasional low-dose use has limited effect. Additive sedation can also occur.
What this interaction means in plain words
Aripiprazole and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated CYP3A4 induction increasing aripiprazole clearance, plus additive CNS depression.
What to do
Monitor for reduced antipsychotic response if butalbital is used regularly, and counsel on sedation; adjust the aripiprazole dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Butalbital?
MediHelp rates the interaction as moderate. Aripiprazole and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce CYP3A4 and lower aripiprazole exposure, although occasional low-dose use has limited effect. Additive sedation can also occur.
How serious is the interaction between Aripiprazole and Butalbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antipsychotic response if butalbital is used regularly, and counsel on sedation; adjust the aripiprazole dose according to response.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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