Drug interactions
Aripiprazole + Butorphanol
Severity: Moderate
Aripiprazole and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole can cause somnolence, and with an opioid this may be intensified. Dizziness and impaired coordination may increase fall risk.
What this interaction means in plain words
Aripiprazole and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Butorphanol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects from opioid agonism and antipsychotic receptor blockade.
What to do
Monitor for sedation and orthostatic symptoms, especially after dose changes. Lower the opioid dose if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Butorphanol?
MediHelp rates the interaction as moderate. Aripiprazole and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole can cause somnolence, and with an opioid this may be intensified. Dizziness and impaired coordination may increase fall risk.
How serious is the interaction between Aripiprazole and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, especially after dose changes. Lower the opioid dose if drowsiness is excessive.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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