Drug interactions
Aripiprazole + Captopril
Severity: Minor
Aripiprazole and Captopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has alpha-1 blocking activity that can cause orthostatic hypotension. Combined with captopril, this can increase the risk of dizziness and falls.
What this interaction means in plain words
Aripiprazole and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Captopril belongs to Cardiovascular.
Why it happens
Additive hypotension from alpha-1 adrenergic antagonism and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting aripiprazole or adjusting doses, and adjust the antihypertensive if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Captopril?
MediHelp rates the interaction as minor. Aripiprazole and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole has alpha-1 blocking activity that can cause orthostatic hypotension. Combined with captopril, this can increase the risk of dizziness and falls.
How serious is the interaction between Aripiprazole and Captopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting aripiprazole or adjusting doses, and adjust the antihypertensive if needed.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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