Drug interactions
Aripiprazole + Cenobamate
Severity: Moderate
Aripiprazole and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower aripiprazole concentrations, reducing its effectiveness. Both drugs also cause somnolence and dizziness, so sedation can be additive.
What this interaction means in plain words
Aripiprazole and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Cenobamate belongs to Central Nervous System.
Why it happens
CYP3A4 induction by cenobamate increases aripiprazole clearance, plus additive CNS depression.
What to do
Monitor psychiatric response and consider increasing the aripiprazole dose; reassess the dose if cenobamate is stopped. Monitor sedation and coordination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Aripiprazole with Cenobamate?
MediHelp rates the interaction as moderate. Aripiprazole and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower aripiprazole concentrations, reducing its effectiveness. Both drugs also cause somnolence and dizziness, so sedation can be additive.
How serious is the interaction between Aripiprazole and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and consider increasing the aripiprazole dose; reassess the dose if cenobamate is stopped. Monitor sedation and coordination.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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