Drug interactions
Aripiprazole + Citalopram
Severity: Moderate
Aripiprazole and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT prolongation, although aripiprazole has a relatively low liability. The combination is commonly used for augmentation, and the added QT risk is generally small but relevant in at-risk patients.
What this interaction means in plain words
Aripiprazole and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Citalopram belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation; aripiprazole's effect is weak.
What to do
Check ECG and electrolytes in patients with cardiac risk factors or other QT-prolonging drugs. Keep citalopram at or below the maximum labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Citalopram?
MediHelp rates the interaction as moderate. Aripiprazole and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT prolongation, although aripiprazole has a relatively low liability. The combination is commonly used for augmentation, and the added QT risk is generally small but relevant in at-risk patients.
How serious is the interaction between Aripiprazole and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac risk factors or other QT-prolonging drugs. Keep citalopram at or below the maximum labeled dose.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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