Drug interactions
Aripiprazole + Conivaptan
Severity: Moderate
Aripiprazole and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and may increase aripiprazole exposure, raising the risk of dose-related adverse effects such as akathisia, sedation and orthostatic hypotension.
What this interaction means in plain words
Aripiprazole and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated aripiprazole metabolism by conivaptan.
What to do
Reduce the aripiprazole dose to about half while conivaptan is used (its use is short-term), and monitor for adverse effects. Restore the usual dose after conivaptan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Conivaptan?
MediHelp rates the interaction as moderate. Aripiprazole and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a strong CYP3A4 inhibitor and may increase aripiprazole exposure, raising the risk of dose-related adverse effects such as akathisia, sedation and orthostatic hypotension.
How serious is the interaction between Aripiprazole and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the aripiprazole dose to about half while conivaptan is used (its use is short-term), and monitor for adverse effects. Restore the usual dose after conivaptan is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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