Drug interactions
Aripiprazole + Danazol
Severity: Moderate
Aripiprazole and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may raise aripiprazole exposure, since aripiprazole is cleared by CYP3A4 and CYP2D6. Higher levels may increase adverse effects such as akathisia, sedation and orthostatic hypotension.
What this interaction means in plain words
Aripiprazole and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of aripiprazole, reducing its clearance.
What to do
Monitor for aripiprazole adverse effects and consider reducing the aripiprazole dose if toxicity appears. If a CYP2D6 inhibitor is also used, follow labeled dose reductions for combined inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Danazol?
MediHelp rates the interaction as moderate. Aripiprazole and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and may raise aripiprazole exposure, since aripiprazole is cleared by CYP3A4 and CYP2D6. Higher levels may increase adverse effects such as akathisia, sedation and orthostatic hypotension.
How serious is the interaction between Aripiprazole and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aripiprazole adverse effects and consider reducing the aripiprazole dose if toxicity appears. If a CYP2D6 inhibitor is also used, follow labeled dose reductions for combined inhibition.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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