Drug interactions
Aripiprazole + Darifenacin
Severity: Minor
Aripiprazole and Darifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin inhibits CYP2D6, one of the main enzymes that metabolize aripiprazole, which may raise aripiprazole levels. Aripiprazole has little anticholinergic activity so additive effects are small.
What this interaction means in plain words
Aripiprazole and Darifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Darifenacin belongs to Genitourinary.
Why it happens
Modest CYP2D6 inhibition by darifenacin reduces aripiprazole clearance.
What to do
Monitor for aripiprazole adverse effects such as akathisia and sedation. Dose adjustment is rarely required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Darifenacin?
MediHelp rates the interaction as minor. Aripiprazole and Darifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin inhibits CYP2D6, one of the main enzymes that metabolize aripiprazole, which may raise aripiprazole levels. Aripiprazole has little anticholinergic activity so additive effects are small.
How serious is the interaction between Aripiprazole and Darifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aripiprazole adverse effects such as akathisia and sedation. Dose adjustment is rarely required.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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