Drug interactions
Aripiprazole + Dextroamphetamine
Severity: Minor
Aripiprazole and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine's stimulant effects oppose the sedation of aripiprazole, and antipsychotics can blunt amphetamine effects through dopamine blockade. There is little evidence of a harmful interaction, and the combination is used in practice for ADHD with psychiatric comorbidity.
What this interaction means in plain words
Aripiprazole and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on dopaminergic transmission and arousal.
What to do
No dose change is routinely needed; monitor response of ADHD symptoms and psychotic symptoms. Watch for worsening agitation or akathisia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Dextroamphetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Dextroamphetamine?
MediHelp rates the interaction as minor. Aripiprazole and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dextroamphetamine's stimulant effects oppose the sedation of aripiprazole, and antipsychotics can blunt amphetamine effects through dopamine blockade. There is little evidence of a harmful interaction, and the combination is used in practice for ADHD with psychiatric comorbidity.
How serious is the interaction between Aripiprazole and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor response of ADHD symptoms and psychotic symptoms. Watch for worsening agitation or akathisia.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
