Drug interactions
Aripiprazole + Diamorphine
Severity: Moderate
Aripiprazole and Diamorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diamorphine (heroin) is a potent opioid, and combining it with aripiprazole can add to sedation, hypotension, and respiratory depression. The risk is greater at higher opioid doses or with other depressants.
What this interaction means in plain words
Aripiprazole and Diamorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedative effects.
What to do
Start with low opioid doses and monitor sedation, respiratory rate, and blood pressure. Avoid adding other CNS depressants where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Diamorphine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Diamorphine?
MediHelp rates the interaction as moderate. Aripiprazole and Diamorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diamorphine (heroin) is a potent opioid, and combining it with aripiprazole can add to sedation, hypotension, and respiratory depression. The risk is greater at higher opioid doses or with other depressants.
How serious is the interaction between Aripiprazole and Diamorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low opioid doses and monitor sedation, respiratory rate, and blood pressure. Avoid adding other CNS depressants where possible.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
