Drug interactions
Aripiprazole + Diltiazem
Severity: Moderate
Aripiprazole and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4, one of the two main pathways clearing aripiprazole, and may increase aripiprazole exposure. This can lead to more akathisia, sedation, orthostatic hypotension or other dose-related effects.
What this interaction means in plain words
Aripiprazole and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Diltiazem belongs to Cardiovascular.
Why it happens
Moderate CYP3A4 inhibition by diltiazem reduces aripiprazole clearance.
What to do
Monitor for adverse effects and reduce the aripiprazole dose if they appear. Follow the labelled dose reductions if a CYP2D6 inhibitor or poor metaboliser status is also present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Diltiazem?
MediHelp rates the interaction as moderate. Aripiprazole and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem inhibits CYP3A4, one of the two main pathways clearing aripiprazole, and may increase aripiprazole exposure. This can lead to more akathisia, sedation, orthostatic hypotension or other dose-related effects.
How serious is the interaction between Aripiprazole and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and reduce the aripiprazole dose if they appear. Follow the labelled dose reductions if a CYP2D6 inhibitor or poor metaboliser status is also present.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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