Drug interactions
Aripiprazole + Donepezil
Severity: Moderate
Aripiprazole and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can prolong the QT interval and cause bradycardia, and aripiprazole has a small potential for QT effects. Combined use is common in dementia-related psychosis and the risk is mainly in patients with additional risk factors.
What this interaction means in plain words
Aripiprazole and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation; donepezil also adds vagotonic bradycardia.
What to do
Check baseline ECG and electrolytes in at-risk patients and monitor heart rate and symptoms such as syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Aripiprazole with Donepezil?
MediHelp rates the interaction as moderate. Aripiprazole and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil can prolong the QT interval and cause bradycardia, and aripiprazole has a small potential for QT effects. Combined use is common in dementia-related psychosis and the risk is mainly in patients with additional risk factors.
How serious is the interaction between Aripiprazole and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in at-risk patients and monitor heart rate and symptoms such as syncope.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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