Drug interactions
Aripiprazole + Encorafenib
Severity: Moderate
Aripiprazole and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can prolong QT in a dose-dependent manner. Combined with aripiprazole, QT effects may be additive. Encorafenib also induces CYP3A4, which could lower aripiprazole levels.
What this interaction means in plain words
Aripiprazole and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Encorafenib belongs to Oncology.
Why it happens
Additive QT prolongation, plus CYP3A4 induction by encorafenib.
What to do
Monitor ECG and electrolytes, and watch for reduced antipsychotic effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Aripiprazole with Encorafenib?
MediHelp rates the interaction as moderate. Aripiprazole and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can prolong QT in a dose-dependent manner. Combined with aripiprazole, QT effects may be additive. Encorafenib also induces CYP3A4, which could lower aripiprazole levels.
How serious is the interaction between Aripiprazole and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for reduced antipsychotic effect.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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