Drug interactions
Aripiprazole + Epinephrine racemic
Severity: Minor
Aripiprazole and Epinephrine racemic: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine is usually given by inhalation, with limited systemic exposure. Antipsychotics with alpha-blocking action may blunt the pressor response to systemic epinephrine, but this is of little relevance with inhaled use.
What this interaction means in plain words
Aripiprazole and Epinephrine racemic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Alpha-1 adrenergic antagonism by aripiprazole may oppose epinephrine vasoconstriction.
What to do
No action is needed for inhaled use; if systemic epinephrine is required, monitor blood pressure and heart rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Epinephrine racemic?
MediHelp rates the interaction as minor. Aripiprazole and Epinephrine racemic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Racemic epinephrine is usually given by inhalation, with limited systemic exposure. Antipsychotics with alpha-blocking action may blunt the pressor response to systemic epinephrine, but this is of little relevance with inhaled use.
How serious is the interaction between Aripiprazole and Epinephrine racemic?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for inhaled use; if systemic epinephrine is required, monitor blood pressure and heart rate.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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