Drug interactions
Aripiprazole + Epinephrine
Severity: Moderate
Aripiprazole and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has alpha-1 adrenergic blocking activity, which may blunt the pressor response to epinephrine and cause unopposed beta-mediated vasodilation and hypotension. This is mainly relevant when epinephrine is given systemically, such as in anaphylaxis or resuscitation.
What this interaction means in plain words
Aripiprazole and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Epinephrine belongs to Endocrine.
Why it happens
Alpha-1 adrenergic antagonism by aripiprazole counteracts the vasoconstrictor effect of epinephrine.
What to do
Monitor blood pressure closely if systemic epinephrine is given and use a pure alpha-agonist vasopressor such as norepinephrine or phenylephrine if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Aripiprazole with Epinephrine?
MediHelp rates the interaction as moderate. Aripiprazole and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole has alpha-1 adrenergic blocking activity, which may blunt the pressor response to epinephrine and cause unopposed beta-mediated vasodilation and hypotension. This is mainly relevant when epinephrine is given systemically, such as in anaphylaxis or resuscitation.
How serious is the interaction between Aripiprazole and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely if systemic epinephrine is given and use a pure alpha-agonist vasopressor such as norepinephrine or phenylephrine if hypotension persists.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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