Drug interactions
Aripiprazole + Esketamine
Severity: Minor
Aripiprazole and Esketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole can cause somnolence and dizziness, and esketamine causes sedation and dissociation. Together, sedation may be additive, although the combination is often used in treatment-resistant depression.
What this interaction means in plain words
Aripiprazole and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Mild additive CNS depressant effects.
What to do
Monitor sedation and blood pressure during esketamine sessions; no routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Esketamine?
MediHelp rates the interaction as minor. Aripiprazole and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole can cause somnolence and dizziness, and esketamine causes sedation and dissociation. Together, sedation may be additive, although the combination is often used in treatment-resistant depression.
How serious is the interaction between Aripiprazole and Esketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during esketamine sessions; no routine dose adjustment is needed.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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