Drug interactions
Aripiprazole + Fentanyl intranasal
Severity: Moderate
Aripiprazole and Fentanyl intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can increase drowsiness, dizziness and impaired psychomotor performance. Respiratory depression and hypotension are possible, particularly in opioid-naive patients or at higher doses.
What this interaction means in plain words
Aripiprazole and Fentanyl intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic sedative and antihistaminic/alpha-blocking effects.
What to do
Use the lowest effective fentanyl dose and monitor sedation and respiratory rate. Warn patients about driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Fentanyl intranasal?
MediHelp rates the interaction as moderate. Aripiprazole and Fentanyl intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can increase drowsiness, dizziness and impaired psychomotor performance. Respiratory depression and hypotension are possible, particularly in opioid-naive patients or at higher doses.
How serious is the interaction between Aripiprazole and Fentanyl intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fentanyl dose and monitor sedation and respiratory rate. Warn patients about driving and other hazardous activities.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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