Drug interactions
Aripiprazole + Fentanyl
Severity: Moderate
Aripiprazole and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole may add to drowsiness and orthostatic hypotension from fentanyl. The effect is generally modest, but sedation can be more pronounced in elderly or opioid-naive patients.
What this interaction means in plain words
Aripiprazole and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive CNS depression through different pharmacodynamic mechanisms.
What to do
Monitor for sedation and orthostatic hypotension, particularly when starting or titrating either drug, and reduce the dose if drowsiness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Fentanyl?
MediHelp rates the interaction as moderate. Aripiprazole and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole may add to drowsiness and orthostatic hypotension from fentanyl. The effect is generally modest, but sedation can be more pronounced in elderly or opioid-naive patients.
How serious is the interaction between Aripiprazole and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, particularly when starting or titrating either drug, and reduce the dose if drowsiness develops.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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