Drug interactions
Aripiprazole + Fexinidazole
Severity: Major
Aripiprazole and Fexinidazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval, and aripiprazole has a small additive potential for this effect. Fexinidazole may also inhibit CYP3A4, which could raise aripiprazole exposure and the risk of adverse effects.
What this interaction means in plain words
Aripiprazole and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation plus possible CYP3A4 inhibition by fexinidazole reducing aripiprazole clearance.
What to do
Avoid the combination where possible; if it is necessary, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc and aripiprazole adverse effects. Consider reducing the aripiprazole dose while fexinidazole is being given.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Abilify 1 mg/mL Oral Solution - SmPC sections 4.3/4.5 (class statement: medicinal products known to cause QT prolongation; "If aripiprazole is administered concomitantly with medicinal products known to cause QT prolongation or electrolyte imbalance, caution should be used.") — electronic medicines compendium (UK SmPC)
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Fexinidazole?
MediHelp rates the interaction as major. Aripiprazole and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval, and aripiprazole has a small additive potential for this effect. Fexinidazole may also inhibit CYP3A4, which could raise aripiprazole exposure and the risk of adverse effects.
How serious is the interaction between Aripiprazole and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc and aripiprazole adverse effects. Consider reducing the aripiprazole dose while fexinidazole is being given.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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