Drug interactions
Aripiprazole + Fosamprenavir
Severity: Moderate
Aripiprazole and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir, a CYP3A4 inhibitor, usually boosted with ritonavir) can raise aripiprazole concentrations. This increases the risk of akathisia, sedation, and orthostatic hypotension.
What this interaction means in plain words
Aripiprazole and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated aripiprazole metabolism.
What to do
Reduce the aripiprazole dose to about half the usual dose in line with labeling for strong CYP3A4 inhibitors, and monitor for adverse effects. Return to the usual dose after the inhibitor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Fosamprenavir?
MediHelp rates the interaction as moderate. Aripiprazole and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir (as amprenavir, a CYP3A4 inhibitor, usually boosted with ritonavir) can raise aripiprazole concentrations. This increases the risk of akathisia, sedation, and orthostatic hypotension.
How serious is the interaction between Aripiprazole and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the aripiprazole dose to about half the usual dose in line with labeling for strong CYP3A4 inhibitors, and monitor for adverse effects. Return to the usual dose after the inhibitor is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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