Drug interactions
Aripiprazole + Gemtuzumab
Severity: Moderate
Aripiprazole and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin carries a QT prolongation warning, and aripiprazole may have a small effect on QT interval. Using both could increase the risk of arrhythmia, especially with electrolyte disturbances.
What this interaction means in plain words
Aripiprazole and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check ECG and electrolytes at baseline and during treatment, correcting potassium and magnesium. Consider an alternative if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Gemtuzumab?
MediHelp rates the interaction as moderate. Aripiprazole and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin carries a QT prolongation warning, and aripiprazole may have a small effect on QT interval. Using both could increase the risk of arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Aripiprazole and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and during treatment, correcting potassium and magnesium. Consider an alternative if QTc becomes markedly prolonged.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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