Drug interactions
Aripiprazole + Glimepiride-pioglitazone
Severity: Minor
Aripiprazole and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can raise blood glucose and worsen glycemic control. Aripiprazole has a relatively low metabolic liability, but control may still deteriorate.
What this interaction means in plain words
Aripiprazole and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Antipsychotic-related insulin resistance and reduced insulin secretion oppose antidiabetic therapy.
What to do
Monitor blood glucose and HbA1c after starting aripiprazole and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Aripiprazole and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics can raise blood glucose and worsen glycemic control. Aripiprazole has a relatively low metabolic liability, but control may still deteriorate.
How serious is the interaction between Aripiprazole and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting aripiprazole and adjust antidiabetic therapy as needed.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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