Drug interactions
Aripiprazole + Grapefruit
Severity: Minor
Aripiprazole and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and might modestly raise aripiprazole levels. Aripiprazole is also cleared by CYP2D6, so the effect is generally small.
What this interaction means in plain words
Aripiprazole and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 by furanocoumarins in grapefruit.
What to do
No restriction is usually required; advise consistent intake and report new akathisia or sedation. Consider avoiding large amounts of grapefruit if the patient is also on a CYP2D6 inhibitor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Grapefruit?
MediHelp rates the interaction as minor. Aripiprazole and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and might modestly raise aripiprazole levels. Aripiprazole is also cleared by CYP2D6, so the effect is generally small.
How serious is the interaction between Aripiprazole and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No restriction is usually required; advise consistent intake and report new akathisia or sedation. Consider avoiding large amounts of grapefruit if the patient is also on a CYP2D6 inhibitor.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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