Drug interactions
Aripiprazole + Henbane
Severity: Moderate
Aripiprazole and Henbane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are potent antimuscarinic alkaloids. Together with aripiprazole they may add to anticholinergic effects such as dry mouth, constipation, urinary retention, tachycardia and confusion.
What this interaction means in plain words
Aripiprazole and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Avoid henbane products where possible. If used, monitor for anticholinergic toxicity including confusion and urinary retention, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Henbane?
MediHelp rates the interaction as moderate. Aripiprazole and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are potent antimuscarinic alkaloids. Together with aripiprazole they may add to anticholinergic effects such as dry mouth, constipation, urinary retention, tachycardia and confusion.
How serious is the interaction between Aripiprazole and Henbane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid henbane products where possible. If used, monitor for anticholinergic toxicity including confusion and urinary retention, especially in older patients.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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